University of Pennsylvania

Table of Contents

Section I | Introduction

• Scope
• Responsibilities

Section II | How to Prepare a Chemical Hygiene Plan

• Standard Operating Procedures
• Documentation Requirements
• Training Requirements

Section III | Hazardous Chemicals

• General
• Irritants
• Simple Asphyxiants
• Anesthetics
• Hepatotoxic Agents
• Nephrotoxic Agents
• Neurotoxic Agents
• Hematopoietic Agents
• Carcinogens
• Reproductive Hazards
• Acutely Toxic Chemicals
• Extremely Toxic Chemicals

Section IV | Labels

• General
• Special Labeling Requirements

Section V | Handling of Chemicals

• General
• Laboratory Fume Hoods
• Personnel Protective Equipment
• Eye Protection
• Lab Coats
• Glove Selection
• Use of Respirators
• Designated Areas

Section VI | Chemical Storage and Transportation

• Segregation
• Chemical Storage Outside the Lab
• Flammable and Combustible Liquid Storage
• Chemical Stability
• Shock Sensitive Chemicals
• Designated Areas
• Compressed Gases
• Transportation of Hazardous Chemicals

Section VII | Room Signs

Section VIII | Laboratory Chemical Waste Disposal Guidelines

Section IX | Material Safety Data Sheets

Section X | Chemical Spills

• General Information
• Spill Cleanup Supplies
• Hazardous Spills

Section XI | Medical Consultation

Section XII | Personal Contamination

• Chemicals Spilled Over a Large Area of the Body
• Chemicals in the Eyes
• Ingestion of Hazardous Chemicals

Section XIII | Fire and Fire Related Emergencies

Section XIV | Industrial Toxicology Overview

• Dose-Response Relationships
• Routes of Entry
• Health Effects

Section XV | Notices to Employees

• Employee Rights
• Protective Equipment
• Educational Programs

Section XVI | Standard Operating Procedures & Fact Sheets

• Laboratory Safety Fact Sheet: Flammable & Combustible Liquid Storage & Dispensing [pdf]
• Laboratory Safety Fact Sheet: Working Safely with Ethidium Bromide | [pdf]
• Laboratory Safety Fact Sheet: Phenol-Chloroform Extraction
• Laboratory Safety Fact Sheet: Cryogen & Dry Ice [pdf]
• Laboratory Safety Fact Sheet: Ultraviolet Radiation Hazards | [pdf]
• Laboratory Safety Fact Sheet: Hazardous Gas Guidelines | [pdf]
• Laboratory Safety Fact Sheet: Hydrofluoric Acid | [pdf]
• Laboratory Safety Fact Sheet: Safety Handling of Nanoparticles [PDF]
• Acutely Toxic Chemicals
• Acutely Toxic Gases
• Carcinogens
• Compressed Gases
• Corrosive Liquids
• Cryogen & Dry Ice [pdf]
• Flammable Liquids
• Oxidizing Chemicals
• Pyrophoric Chemicals
• Reactive Solids
• Reproductive Hazards
• Water Sensitive Chemicals
• Reactive Liquids
• Animal Inhalation Anesthetics
• Electrical Safety

Section XVII | Glossary

Section XVIII | References

Appendicies

• Appendix A | List of Acutely Toxic Gases
• Appendix B | List of Acutely Toxic Chemicals
• Appendix C | List of Select and Suspected Carcinogens
• Appendix D | Reproductive Hazards
• Appendix E | Chemical Hygiene Work Plan
• Appendix F | Notification of the Use of Acutely Toxic, Carcinogenic, or Reproductive Hazards
• Appendix G | Chemical Hygiene Designated Area Tape and Label Order Form
• Appendix H | Information Request
• Appendix I | Room Sign Request Form
• Appendix J | Chemical Storage Sign Request Form
• Appendix K | Chemical Hygiene Self Evaluation Form
• Appendix L | Formaldehyde Safety Information
• Appendix M | Hydrofluoric Acid First Aid Kit Order Form